Protection against Microglia Senescence by the Dietary Supplement Dekosilhue® in BV2 Cells: A New Perspective for Obesity and Related Complications

Growing evidence indicates chronic low-grade systemic inflammation as a major pathophysiological mechanism of obesity. Systemic provokes an immune response in the brain through activation microglia that results development neuroinflammation, cellular senescence, and occurrence neurological dysfunction. In efforts to identify innovative intervention with potential efficacy on obesity associated complications, our aim was study capability dietary supplement Dekosilhue® (DKS), successfully used for improving control body weight, attenuate senescent phenotype. Microglia senescence induced by intermittent stimulation BV2 cells LPS 500 ng/mL every 72 h 4 h/day, over period 10 days. DKS (100 µg/mL) treatment reduced ß-galactosidase activity expression, formation senescence-associated heterochromatin foci levels, increased cell viability (2 folds control). DSK expression Nuclear Factor-kB (NF-kB) (20% lower than control), key molecule involved acquisition secretory phenotype (SASP). promoted neuroprotective effect increasing SH-SY5Y neuronal exposed conditioned medium values non-senescent cells. conclusion, attenuated phenotype, showing senotherapeutic might be further investigated adjunctive obesity-related disturbances.